Medical Laboratory Technology Journal 2022-07-23T14:43:52+07:00 Leka Lutpiatina Open Journal Systems <p style="text-align: justify;">Medical Laboratory Technology Journal, with registered number ISSN 2461-0879 (online) is a scientific journal published by <a href="">Poltekkes Kemenkes Banjarmasin</a> in cooperation with <a href="">PATELKI</a> with the <a href="">MOU</a>. The aim of this journal publication is to disseminate the conceptual thoughts or ideas and research results that have achieved in the area of medical laboratory sciences. This Journal particularly focuses on the main problems in the development of the sciences of medical laboratory areas. It covers the parasitology, bacteriology, virology, hematology, clinical chemistry, toxicology, food and drink chemistry, and any sciences that cover sciences of medical laboratory area. Please read these guidelines carefully. Authors who want to submit their manuscript to the editorial office of Medical Laboratory Technology Journal should obey the writing guidelines. If the manuscript submitted is not appropriate with the guidelines or written in a different format, it will BE REJECTED by the editors before further reviewed. The editors will only accept the manuscripts which meet the assigned format.</p> <p style="text-align: justify;">Medical Laboratory Technology Journal (MLTJ) has been reaccredited by Ministry of Research, Technology, and Higher Education of Republic of Indonesia since Vol. 4, No. 2, 2018 until Vol. 9, No. 1, 2023 with grade 2nd according to the <a href="">decree No. 10/E/KPT/2019</a> and <a href="" target="_blank" rel="noopener">Official Certificate. </a></p> Effect of Papaya Leaf Extract Gel (Carica papaya) on Incision Wound Healing in Rattus norvegicus 2022-07-23T14:43:52+07:00 Iin Tri Marlinawati Siti Nurhidayah Sanarto Santoso Yahya Irwanto <em>Carica papaya</em> is one kind of herbal plant that can help the wound healing process. Scientifically, the leaves of papaya are proven to have anti-inflammatory effects. Flavonoid, alkaloid, tannin, and saponin compounds in papaya leaves have antimicrobial and antioxidant properties to accelerate the re-epithelization and cell migration needed for wound healing. This research aims to determine the effect of papaya leaf extract gel <em>(Carica </em><em>papaya)</em> on the healing of incision wounds in <em>Ra</em><em>ttus norvegicus</em> based on changes in wound morphology (signs of redness, edema, pus, granulation, moisture, and wound length). This research used female <em>Rattus norvegicus</em> aged 12-16 weeks weighing 180-200 grams, divided into five groups (NaCl 0,9%, povidone-iodine, papaya leaf extract gel with concentrations of 10%, 20%, and 30%). Incision wounds on the back of the rat with a length of 2 cm and depth of 1 cm. The normality test used the Shapiro-Wilk test, and the homogeneity test used the Levene test. The research data were not normally distributed nor homogeneous, so they were analyzed using the Kruskal Wallis and Mann-Whitney tests. The results showed that the extract of papaya leaves with concentrations of 10%, 20%, and 30% had significant differences in positive and negative control groups in the wound healing process with the differences in redness (p=0.038), granulation tissue (p=0.039), moistures (0,48), and wound length (p=0,049). It can be concluded that papaya leaf extract gel <em>(Carica papaya)</em> is effective in accelerating the healing process of incision wounds in <em>Rattus norwegicus</em> at concentrations of 10%, 20%, and 30%, so for further research, it is hoped that a histopathological examination can be carried out so that changes that occur in collagen, neutrophile cells, monocytes, and lymphocytes are seen. 2022-07-23T00:00:00+07:00 Copyright (c) 2022 Iin Tri Marlinawati