Creatinine Clearance in Patients with Obstructive Sleep Apnea
DOI:
https://doi.org/10.31964/mltj.v7i1.378Keywords:
Creatinine, hypertension, obstructive sleep apnea, renal dysfunctionAbstract
During an apnea, hemodynamic complications such as hypoxemia, a rise in systemic and pulmonary arterial pressure, and changes in heart rate occur in patients with obstructive sleep apnea (OSA). Potential mechanisms of OSA-associated renal dysfunction include renal hypoxia, hypertension, endothelial dysfunction. Hypertension is common in patients with OSA. This study aims to assess OSA patients' renal functions and investigate the creatinine clearance (CC) values across OSA patients with and without hypertension. The study included 530 individuals with OSA and 60 individuals with an apnea-hypopnea index (AHI) of 0.05). A statistically significant difference was detected in urea and creatinine levels between the OSA and control groups (p=0.005; p=0.012). Creatinine clearance decreases in patients with OSA in the presence of HT. Patients with OSA often experience cardiovascular disorders, and glomerular endothelial dysfunction occurs in OSA patients.References
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Faulx M. D, Storfer-Isser A, Kirchner H.L, Jenny N. S, Tracy R. P. Redline S. (2007). Obstructive sleep apnea is associated with increased urinary albumin excretion. Sleep, 30(7), 923-929.
Hwu, DW., Lin, KD., Lin, KC. et al. (2017). The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis. BMC Nephrol, 18, 313.
Inal BB, Şahin M, Bilgi PT, Aral H, Yiğit S, Topkaya Ç, et al. (2009). Obstrüktif uyku apne sendromlu hastalarda kreatinin klirensinin değerlendirilmesi. İstanbul Tıp Dergisi, 10(3),130-2.
Iseki K, Tohyama K, Matsumoto T, et al. (2008). High Prevalence of chronic kidney disease among patients with sleep related breathing disorder (SRBD). Hypertens Res, 31, 249-55.
James M. Parish, and Virend K. Somers. (2004). Obstructive Sleep Apnea and Cardiovacular Disease. Mayo Clin Proc, 79(8), 1036-1046
Karakaş S, Ozbek SC, Akdemir B, Er A,Yanıkoğlu A, Altekin RE, Baktır AO, Yalcınkaya S, Cilli A. (2012). Obstrüktif Uyku Apne Sendromu Olan Normotansif Hastalarda Böbrek Fonksiyonlarının Değerlendirilmesi. Erciyes Med J, 34(3), 137-40
Kinebuchi S, Kazama JJ, Satoh M, et al. (2004). Short-term use of continuous positive airway pressure ameliorates glomerular hyperfiltration in patients with obstructive sleep apnoea syndrome. Clin Sci (Lond), 107, 317-22
Koga S, Ikeda S, Yasunaga T, Nakata T, Maemura K. (2013). Effects of nasal continuous positive airway pressure on the glomerular filtration rate in patients with obstructive sleep apnea syndrome. Intern Med, 52, 345–9.
Koktürk O, Tatlıcıoğlu T, Kemaloğlu Y, Fırat H, Çetin N. (1997). Habituel horlaması olan olgularda obstrüktif sleep apne sendromu prevelansı. Tüberküloz ve Toraks, 45(1), 7-11.
Lavie P, Ben-Yosef R, Rubin AE. (1984). Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J, 108(2), 373-6
Lindberg E, Gislason T. (2000). Epidemiology of sleeprelated obstructive breathing. Sleep Med Rev, 4, 41133
Liu, T., Zhan, Y., Wang, Y., Li, Q., & Mao, H. (2021). Obstructive sleep apnea syndrome and risk of renal impairment: a systematic review and meta-analysis with trial sequential analysis. Sleep & Breathing = Schlaf & Atmung, 25(1), 17–27
Mallamaci F, Tripepi G. (2011). Comment accompanying obstructive sleep apnoea: a stand-alone risk factor for chronic kidney disease. Nephrol Dial Transplant, 26(7), 2072-4
Schwab RJ, Goldberg AN, Pack AL. (1998). Sleep apnea syndromes. Fishman’s Pulmonary Diseases and Disorders. Ed: Fishman AP. New York: Mc Graw-Hill Book Company. pp: 1617-37.
Shahar E, Whitney CW, Redline S, et al. (2001). Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med, 163, 19–25
Tsioufis C, Thomopoulos C, Dimitriadis K, et al. (2008). Association of obstructive sleep apnea with urinary albumin excretion in essential hypertension: a crosssectional study. Am J Kidney Dis, 52, 285–93.
Uyar M, Davutoğlu V, Gündoğdu N, et al. (2016). Renal functions in obstructive sleep apnea patients. Sleep Breath, 20,191-5.
Adeseun GA, Rosas SE. (2010). The impact of obstructive sleep apnea on chronic kidney disease. Curr Hypertens Rep,12, 378–83.
Agrawal V, Vanhecke TE, Rai B, Franklin BA, Sangal RB, McCullough PA. (2009). Albuminuria and renal function in obese adults evaluated for obstructive sleep apnea. Nephron Clin Pract, 113, c140–7.
Ahmed SB, Ronksley PE, Hemmelgarn BR, et al. (2011). Nocturnal hypoxia and loss of kidney function. PLoS One, 6, e19029.
Di Murro A, Petramala L, Cotesta D, et al. (2010). Renin-angiotensin-aldosterone system in patients with sleep apnoea: prevalence of primary aldosteronism. J Renin Angiotensin Aldosterone Syst, 11, 165–72.
Faulx M. D, Storfer-Isser A, Kirchner H.L, Jenny N. S, Tracy R. P. Redline S. (2007). Obstructive sleep apnea is associated with increased urinary albumin excretion. Sleep, 30(7), 923-929.
Hwu, DW., Lin, KD., Lin, KC. et al. (2017). The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis. BMC Nephrol, 18, 313.
Inal BB, Şahin M, Bilgi PT, Aral H, Yiğit S, Topkaya Ç, et al. (2009). Obstrüktif uyku apne sendromlu hastalarda kreatinin klirensinin değerlendirilmesi. İstanbul Tıp Dergisi, 10(3),130-2.
Iseki K, Tohyama K, Matsumoto T, et al. (2008). High Prevalence of chronic kidney disease among patients with sleep related breathing disorder (SRBD). Hypertens Res, 31, 249-55.
James M. Parish, and Virend K. Somers. (2004). Obstructive Sleep Apnea and Cardiovacular Disease. Mayo Clin Proc, 79(8), 1036-1046
Karakaş S, Ozbek SC, Akdemir B, Er A,Yanıkoğlu A, Altekin RE, Baktır AO, Yalcınkaya S, Cilli A. (2012). Obstrüktif Uyku Apne Sendromu Olan Normotansif Hastalarda Böbrek Fonksiyonlarının Değerlendirilmesi. Erciyes Med J, 34(3), 137-40
Kinebuchi S, Kazama JJ, Satoh M, et al. (2004). Short-term use of continuous positive airway pressure ameliorates glomerular hyperfiltration in patients with obstructive sleep apnoea syndrome. Clin Sci (Lond), 107, 317-22
Koga S, Ikeda S, Yasunaga T, Nakata T, Maemura K. (2013). Effects of nasal continuous positive airway pressure on the glomerular filtration rate in patients with obstructive sleep apnea syndrome. Intern Med, 52, 345–9.
Koktürk O, Tatlıcıoğlu T, Kemaloğlu Y, Fırat H, Çetin N. (1997). Habituel horlaması olan olgularda obstrüktif sleep apne sendromu prevelansı. Tüberküloz ve Toraks, 45(1), 7-11.
Lavie P, Ben-Yosef R, Rubin AE. (1984). Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J, 108(2), 373-6
Lindberg E, Gislason T. (2000). Epidemiology of sleeprelated obstructive breathing. Sleep Med Rev, 4, 41133
Liu, T., Zhan, Y., Wang, Y., Li, Q., & Mao, H. (2021). Obstructive sleep apnea syndrome and risk of renal impairment: a systematic review and meta-analysis with trial sequential analysis. Sleep & Breathing = Schlaf & Atmung, 25(1), 17–27
Mallamaci F, Tripepi G. (2011). Comment accompanying obstructive sleep apnoea: a stand-alone risk factor for chronic kidney disease. Nephrol Dial Transplant, 26(7), 2072-4
Schwab RJ, Goldberg AN, Pack AL. (1998). Sleep apnea syndromes. Fishman’s Pulmonary Diseases and Disorders. Ed: Fishman AP. New York: Mc Graw-Hill Book Company. pp: 1617-37.
Shahar E, Whitney CW, Redline S, et al. (2001). Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med, 163, 19–25
Tsioufis C, Thomopoulos C, Dimitriadis K, et al. (2008). Association of obstructive sleep apnea with urinary albumin excretion in essential hypertension: a crosssectional study. Am J Kidney Dis, 52, 285–93.
Uyar M, Davutoğlu V, Gündoğdu N, et al. (2016). Renal functions in obstructive sleep apnea patients. Sleep Breath, 20,191-5.
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Published
2021-06-18
How to Cite
Sagmen, S. B., Kiral, N., Fidan, A., Torun Parmaksiz, E., Dogan, C., & Comert, S. (2021). Creatinine Clearance in Patients with Obstructive Sleep Apnea. Medical Laboratory Technology Journal, 7(1), 59–65. https://doi.org/10.31964/mltj.v7i1.378
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