Creatinine Clearance in Patients with Obstructive Sleep Apnea
Keywords:Creatinine, hypertension, obstructive sleep apnea, renal dysfunction
AbstractDuring an apnea, hemodynamic complications such as hypoxemia, a rise in systemic and pulmonary arterial pressure, and changes in heart rate occur in patients with obstructive sleep apnea (OSA). Potential mechanisms of OSA-associated renal dysfunction include renal hypoxia, hypertension, endothelial dysfunction. Hypertension is common in patients with OSA. This study aims to assess OSA patients' renal functions and investigate the creatinine clearance (CC) values across OSA patients with and without hypertension. The study included 530 individuals with OSA and 60 individuals with an apnea-hypopnea index (AHI) of 0.05). A statistically significant difference was detected in urea and creatinine levels between the OSA and control groups (p=0.005; p=0.012). Creatinine clearance decreases in patients with OSA in the presence of HT. Patients with OSA often experience cardiovascular disorders, and glomerular endothelial dysfunction occurs in OSA patients.
Adeseun GA, Rosas SE. (2010). The impact of obstructive sleep apnea on chronic kidney disease. Curr Hypertens Rep,12, 378–83.
Agrawal V, Vanhecke TE, Rai B, Franklin BA, Sangal RB, McCullough PA. (2009). Albuminuria and renal function in obese adults evaluated for obstructive sleep apnea. Nephron Clin Pract, 113, c140–7.
Ahmed SB, Ronksley PE, Hemmelgarn BR, et al. (2011). Nocturnal hypoxia and loss of kidney function. PLoS One, 6, e19029.
Di Murro A, Petramala L, Cotesta D, et al. (2010). Renin-angiotensin-aldosterone system in patients with sleep apnoea: prevalence of primary aldosteronism. J Renin Angiotensin Aldosterone Syst, 11, 165–72.
Faulx M. D, Storfer-Isser A, Kirchner H.L, Jenny N. S, Tracy R. P. Redline S. (2007). Obstructive sleep apnea is associated with increased urinary albumin excretion. Sleep, 30(7), 923-929.
Hwu, DW., Lin, KD., Lin, KC. et al. (2017). The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis. BMC Nephrol, 18, 313.
Inal BB, Şahin M, Bilgi PT, Aral H, Yiğit S, Topkaya Ç, et al. (2009). Obstrüktif uyku apne sendromlu hastalarda kreatinin klirensinin değerlendirilmesi. İstanbul Tıp Dergisi, 10(3),130-2.
Iseki K, Tohyama K, Matsumoto T, et al. (2008). High Prevalence of chronic kidney disease among patients with sleep related breathing disorder (SRBD). Hypertens Res, 31, 249-55.
James M. Parish, and Virend K. Somers. (2004). Obstructive Sleep Apnea and Cardiovacular Disease. Mayo Clin Proc, 79(8), 1036-1046
Karakaş S, Ozbek SC, Akdemir B, Er A,Yanıkoğlu A, Altekin RE, Baktır AO, Yalcınkaya S, Cilli A. (2012). Obstrüktif Uyku Apne Sendromu Olan Normotansif Hastalarda Böbrek Fonksiyonlarının Değerlendirilmesi. Erciyes Med J, 34(3), 137-40
Kinebuchi S, Kazama JJ, Satoh M, et al. (2004). Short-term use of continuous positive airway pressure ameliorates glomerular hyperfiltration in patients with obstructive sleep apnoea syndrome. Clin Sci (Lond), 107, 317-22
Koga S, Ikeda S, Yasunaga T, Nakata T, Maemura K. (2013). Effects of nasal continuous positive airway pressure on the glomerular filtration rate in patients with obstructive sleep apnea syndrome. Intern Med, 52, 345–9.
Koktürk O, Tatlıcıoğlu T, Kemaloğlu Y, Fırat H, Çetin N. (1997). Habituel horlaması olan olgularda obstrüktif sleep apne sendromu prevelansı. Tüberküloz ve Toraks, 45(1), 7-11.
Lavie P, Ben-Yosef R, Rubin AE. (1984). Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J, 108(2), 373-6
Lindberg E, Gislason T. (2000). Epidemiology of sleeprelated obstructive breathing. Sleep Med Rev, 4, 41133
Liu, T., Zhan, Y., Wang, Y., Li, Q., & Mao, H. (2021). Obstructive sleep apnea syndrome and risk of renal impairment: a systematic review and meta-analysis with trial sequential analysis. Sleep & Breathing = Schlaf & Atmung, 25(1), 17–27
Mallamaci F, Tripepi G. (2011). Comment accompanying obstructive sleep apnoea: a stand-alone risk factor for chronic kidney disease. Nephrol Dial Transplant, 26(7), 2072-4
Schwab RJ, Goldberg AN, Pack AL. (1998). Sleep apnea syndromes. Fishman’s Pulmonary Diseases and Disorders. Ed: Fishman AP. New York: Mc Graw-Hill Book Company. pp: 1617-37.
Shahar E, Whitney CW, Redline S, et al. (2001). Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med, 163, 19–25
Tsioufis C, Thomopoulos C, Dimitriadis K, et al. (2008). Association of obstructive sleep apnea with urinary albumin excretion in essential hypertension: a crosssectional study. Am J Kidney Dis, 52, 285–93.
Uyar M, Davutoğlu V, Gündoğdu N, et al. (2016). Renal functions in obstructive sleep apnea patients. Sleep Breath, 20,191-5.
How to Cite
Publishing your paper with Medical Laboratory Technology Journal (MLTJ) means that the author or authors retain the copyright in the paper. MLTJ granted an author(s) rights to put the paper onto a website, distribute it to colleagues, give it to students, use it in your thesis etc, even commercially. The author(s) can reuse the figures and tables and other information contained in their paper published by MLTJ in future papers or work without having to ask anyone for permission, provided that the figures, tables or other information that is included in the new paper or work properly references the published paper as the source of the figures, tables or other information, and the new paper or work is not direct at private monetary gain or commercial advantage.
MLTJ journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets others remix, transform, and build upon the material for any purpose, even commercially. MLTJ journal Open Access articles are distributed under this Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA). Articles can be read and shared for All purposes under the following conditions:
BY: You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.SA: If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.