Association of the TG/HDL-C and Monocyte Count/HDL-C Ratios with Coronary Artery Disease in Non-ST Segment Elevation Myocardial Infarction

Uğur Küçük, Recep Kurt

Abstract

Monocyte Count/HDL ratio (MHR) is a simple and inexpensive parameter used as a risk predictor in patients diagnosed with myocardial infarction (MI). This study aims to investigate the association between Triglyceride/HDL-C (TG/HDL-C) ratio and coronary artery disease in patients diagnosed with non-ST segment elevation MI (NSTEMI). Total of 100 patients, 50 patients with NSTEMI and 50 healthy individuals, who had admitted to the cardiology outpatient clinic between January 2018 and January 2019 included in the study. Higher monocyte count, MHR, and TG/HDL-C ratios detected in patients with coronary artery disease in comparison to healthy individuals. Although monocyte count was higher in NSTEMI group, the difference was not statistically significant (p=0.101). There was an increase in the MHR NSTEMI group when compared against the control group (p<0.05). In the NSTEMI group, the best cut-off point for MHR value determined as 2.33 with 56% sensitivity and 76% selectivity. TG/HDL-C ratio was found to be numerically higher in the disease group. However, it was not statistically significant (p=0.386). The best cut-off point for the TG/HDL-C ratio determined as 3.33, with 52% sensitivity and 54% selectivity. In the sub-group analyses performed with regards to coronary anatomy, a statistically significant relation was found between MHR and Circumflex (Cx) artery in predicting the lesion responsible for ischemia (p=0.009). Conclusion In our study, MHR (OR=1.725, p=0.030) was found to be statistically significant in NSTEMI patients, and although TG/HDL-C (OR=1.526, p=0.386) ratio was numerically higher than the control group; it was not statistically significant in predicting severe coronary artery disease.

Keywords

Non-ST segment elevation acute coronary syndrome; Triglyceride/HDL cholesterol ratio; Coronary Artery Disease

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