Survival and Clinicopathological Features of Cervical Carcinoma Patients with Radiation Therapy
DOI:
https://doi.org/10.31964/mltj.v0i0.452Keywords:
Survival rate, cervical carcinoma, radiation therapyAbstract
Cervical cancer has a high incidence with a low survival rate. The clinicopathological profile and risk factors cause this. Most cervical cancer sufferers are late in realizing this, contributing to the severity suffered. Radiation has a very important role because it is a therapy that can be done in cervical cancer patients who have experienced an advanced level of severity. This study aims to determine the survival and influence of the clinicopathological and risk factors of radiation patients as a consideration in selecting effective therapy to increase the survival rate of cervical cancer patients. The benefit of this research is to help evaluate cervical cancer management procedures with radiation therapy applied in many hospitals in Indonesia to increase the success of therapy for cervical cancer. An analytical observational study with a retrospective cohort type using medical record data with samples of all patients diagnosed with cervical cancer who received radiation therapy from January to December 2017. Samples in this study were 111 patients. This study revealed that the five-year survival rate of cervical cancer patients was only 53.1%. There was an influence on the clinicopathological stage (p<0.000), histopathology (p<0.000), lymph node status (p<0.000), degree of differentiation (p<0.001), and risk factors for age (p<0.038), parity (p<0.001), education (0.022), marital status (0.001), contraceptive use (p<0.000), and BMI (p<0.000) which resulted in a log-rank p-value <0.05, so it was concluded that there was an effect between these variables on cervical carcinoma survival rate. Multivariate, it was found that radiation, histopathology, lymph node status, contraception, and BMI had a significant effect (p<0.005) on the survival rate of cervical cancer patients. The results of this study indicate that the survival rate of cervical cancer patients is still low, and there is a clinicopathological and risk factors that influence the survival rate of cervical cancer patients.References
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Young Ae Kim, Min Soo Yang, etc. (2021). Brachytherapy utilization rate and effect on survival in cervical cancer patients in Korea. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology. https://www.ejgo.org/DOIx.php?id=10.3802/jgo.2021.32.e85
Andrijono, Purwoto, G., Sekarutami, S. M., Handjari, D. R., Primariadewi, Nuhonni, S. A., Fiastuti, W., Manikam, N. R. M., & Octavia, L. I. (2013). Panduan Penatalaksanaan Kanker Serviks. Komite Penanggulangan Kanker Nasional, 1–30.
Balaya, V., Guani, B., Magaud, L., Bonsang-Kitzis, H., Ngô, C., Mathevet, P., & Lécuru, F. (2020). Validation of the 2018 Figo classification for cervical cancer: Lymphovascular space invasion should be considered in the ib1 stage. Cancers, 12(12), 1–14. https://doi.org/10.3390/cancers12123554
Becker, A. S., Ghafoor, S., Marcon, M., Perucho, J. A., Wurnig, M. C., Wagner, M. W., Khong, P.-L., Lee, E. Y., & Boss, A. (2017). MRI texture features may predict differentiation and nodal stage of cervical cancer: a pilot study. Acta Radiologica Open, 6(10), 205846011772957. https://doi.org/10.1177/2058460117729574
Benitez-restrepo, C. C., & Arias-ortiz, N. E. (2020). Artículo Orıgınal Uterıno Y Sobrevıda De Pacıentes En. Revista Peruana de Medicina Experimental y Salud Publica, 37(3), 438-45, 10.17843/rpmesp.2020.373.4838
.
Bhatla, N., Aoki, D., Sharma, D. N., & Sankaranarayanan, R. (2018). Cancer of the cervix uteri. International Journal of Gynecology and Obstetrics, 143, 22–36. https://doi.org/10.1002/ijgo.12611
Carneiro, S. R., De Araújo Fagundes, M., De Jesus Oliveira do Rosário, P., Neves, L. M. T., Da Silva Souza, G., & Da Conceição Nascimento Pinheiro, M. (2017). Five-year survival and associated factors in women treated for cervical cancer at a reference hospital in the Brazilian Amazon. PLoS ONE, 12(11), 1–11. https://doi.org/10.1371/journal.pone.0187579
Cohen, P. A., Jhingran, A., Oaknin, A., & Denny, L. (2019). Cervical cancer. The Lancet, 393(10167), 169–182. https://doi.org/10.1016/S0140-6736(18)32470-X
Gai, J., Wang, X., Meng, Y., Xu, Z., Kou, M., & Liu, Y. (2019). Clinicopathological factors are influencing the prognosis of cervical cancer. Journal of B.U.ON., 24(1), 291–295.
Iversen, L., Fielding, S., Lidegaard, & Hannaford, P. C. (2021). Contemporary hormonal contraception and cervical cancer in women of reproductive age. International Journal of Cancer, 149(4), 769–777. https://doi.org/10.1002/ijc.33585
Lubis, L. I. (2016). Klinikohistopatologi Pasien Kanker Serviks Dengan Respon Radiasi. Fakultas Kedokteran Universitas Sumatera Utara Medan
Matsuo, K., Mandelbaum, R. S., Machida, H., Purushotham, S., Grubbs, B. H., Roman, L. D., & Wright, J. D. (2018). Association of tumor differentiation grade and survival of women with squamous cell carcinoma of the uterine cervix. Journal of Gynecologic Oncology, 29(6), 1–12. https://doi.org/10.3802/jgo.2018.29.e91
National Health Service. (2015). Complications Cervical Cancer. EGC.
Pusat Data dan Informasi. (2020). Kementerian Kesehatan RI
Pusat Data dan Informasi. (2015). Situasi Penyakit Kanker. Kementerian Kesehatan RI.
Sharma, P., & Pattanshetty, S. M. (2018). A study on risk factors of cervical cancer among patients attending a tertiary care hospital: A case-control study. Clinical Epidemiology and Global Health, 6(2), 83–87. https://doi.org/10.1016/j.cegh.2017.10.001
Sherly, R. (2014). Ketahanan Hidup 1 Tahun Dan Faktor Prognostik Pasien Dengan Kanker Serviks Stadium Lanjut LACC Setelah Radiasi. Universitas Brawijaya.
Sinaga, R. J. (2020). Hubungan Genotipe High Risk Human Papillomavirus 16, 18, dan non 16/18 dengan Jenis Histopatologi dan Status Metastasis kelenjar Getah Bening pada Kanker Serviks Stadium Dini. Universitas Padjadjaran / Fakultas Kedokteran / Obstetri Dan Ginekologi.
Telaumbanua, R. M. (2019). Survıval Rate Penderıta Kanker Servıks Dı RSUP Dr. Sardjıto Yogyakarta, Departemen Kedokteran, Fakultas Masyarakat, Kesehatan Mada, Universitas Gadjah, 4–5.
Wenzel, H. H. B., Bekkers, R. L. M., Lemmens, V. E. P. P., Van der Aa, M. A., & Nijman, H. W. (2021). No improvement in survival of older women with cervical cancer—A nationwide study. European Journal of Cancer, 151, 159–167. https://doi.org/10.1016/j.ejca.2021.04.014
Werestandina, A. (2014). Hubungan Indeks Massa Tubuh (IMT) Dengan Respon Klınıs Kemoradıası Pasıen Kanker Servıks Stadıum III dı RSUD Dr. Saıful Anwar Malang. Thesis. Fakultas Kedokteran Universitas Brawijaya Malang.
Yang, J., Tian, G., Pan, Z., Zhao, F., Feng, X., Liu, Q., & Lyu, J. (2019). Nomograms for predicting the survival rate of cervical cancer patients undergoing radiation therapy: A SEER analysis. Future Oncology, 15(26), 3033–3045. https://doi.org/10.2217/fon-2019-0029
Young Ae Kim, Min Soo Yang, etc. (2021). Brachytherapy utilization rate and effect on survival in cervical cancer patients in Korea. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology. https://www.ejgo.org/DOIx.php?id=10.3802/jgo.2021.32.e85
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Published
2022-06-27
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Irwanto, Y., Wulandari, A. P., Permatasari, I., Ganisia, A., Zuhriyah, L., Indrawan, I. W. A., & ., S. (2022). Survival and Clinicopathological Features of Cervical Carcinoma Patients with Radiation Therapy. Medical Laboratory Technology Journal, 8(1), 84–101. https://doi.org/10.31964/mltj.v0i0.452
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